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- B487ec1af48e0a0bf8097f64bc203a3d3 NCIT_P378 "NCI" @default.
- B487ec1af48e0a0bf8097f64bc203a3d3 type Axiom @default.
- B487ec1af48e0a0bf8097f64bc203a3d3 annotatedProperty IAO_0000115 @default.
- B487ec1af48e0a0bf8097f64bc203a3d3 annotatedSource NCIT_C80333 @default.
- B487ec1af48e0a0bf8097f64bc203a3d3 annotatedTarget "The fumarate salt of an orally-active benzimidazole derivative with potential antineoplastic activity. As a retinoic acid metabolism blocking agent (RAMBA), liarozole inhibits cytochrome P450-dependent all-trans-retinoic acid (ATRA)-4-hydroxylase, resulting in an increase in endogenous ATRA production, inhibition of cell proliferation, and induction of cell differentiation. This agent also inhibits aromatase, the enzyme that catalyzes the final, rate-limiting step in estrogen biosynthesis." @default.