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- B489edda31d393cc2bca5ebc3c4b032b3 NCIT_P378 "NCI" @default.
- B489edda31d393cc2bca5ebc3c4b032b3 type Axiom @default.
- B489edda31d393cc2bca5ebc3c4b032b3 annotatedProperty IAO_0000115 @default.
- B489edda31d393cc2bca5ebc3c4b032b3 annotatedSource NCIT_C2736 @default.
- B489edda31d393cc2bca5ebc3c4b032b3 annotatedTarget "A water-soluble phosphate prodrug of N-acetylcolchinol with potential antiangiogenesis and antineoplastic activities. ZD-6126 is converted in vivo into N-acetylcolchinol. N-acetylcolchinol binds to and destabilizes the tubulin cytoskeleton of endothelial cells in tumor blood vessels, which may result in tumor endothelial cell apoptosis, the selective occlusion of tumor blood vessels, cessation of tumor blood flow, and tumor necrosis." @default.