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- B48fe165fdbbc40b1b78b3f4ac4278c9a NCIT_P378 "NCI" @default.
- B48fe165fdbbc40b1b78b3f4ac4278c9a type Axiom @default.
- B48fe165fdbbc40b1b78b3f4ac4278c9a annotatedProperty IAO_0000115 @default.
- B48fe165fdbbc40b1b78b3f4ac4278c9a annotatedSource NCIT_C154275 @default.
- B48fe165fdbbc40b1b78b3f4ac4278c9a annotatedTarget "A long-acting recombinant fusion protein composed of human serum albumin (HSA) fused to granulocyte colony stimulating factor (G-CSF), with potential granulopoietic activity. Produced endogenously by monocytes, fibroblasts, and endothelial cells, G-CSF binds to and activates specific cell surface receptors, thereby stimulating the proliferation, differentiation, function, and survival of neutrophil precursors and mature neutrophils. This may prevent granulocytopenia. HSA fusion increases the molecular weight of G-CSF, prolongs its half-life and masks G-CSF, thereby preventing G-CSF degradation which further increases the half-life and bioavailability of G-CSF." @default.