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- B491546a170a85261e297dbc5638ff1f5 NCIT_P378 "NCI" @default.
- B491546a170a85261e297dbc5638ff1f5 type Axiom @default.
- B491546a170a85261e297dbc5638ff1f5 annotatedProperty IAO_0000115 @default.
- B491546a170a85261e297dbc5638ff1f5 annotatedSource NCIT_C104414 @default.
- B491546a170a85261e297dbc5638ff1f5 annotatedTarget "A substance that inhibits protein geranylgeranyltransferase type 1 (GGTase-I), with potential antineoplastic activity. GGTase-I is involved in the posttranslational modification of a number of oncogenic GTPases, including K-Ras, N-Ras, RhoA, RhoC, Cdc42, RalA, RalB and Rac1. Inhibition of the prenylation of these oncogenic proteins inhibits both their oncogenic activity and membrane localization. This may result in cell cycle arrest and apoptosis. Protein geranylgeranylation, catayzed by GGTase-I, plays a critical role in malignant transformation and cancer cell proliferation, migration and invasion." @default.