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- B4950e212a5df4833cffba0cda9bb5c1b NCIT_P378 "BIOCARTA" @default.
- B4950e212a5df4833cffba0cda9bb5c1b type Axiom @default.
- B4950e212a5df4833cffba0cda9bb5c1b annotatedProperty NCIT_P325 @default.
- B4950e212a5df4833cffba0cda9bb5c1b annotatedSource NCIT_C39215 @default.
- B4950e212a5df4833cffba0cda9bb5c1b annotatedTarget "Once retinoids are bound by the RAR/RXR heterodimer they became transcriptional activated. As a consequence they are degraded by the proteasome. Phosphorylation in the activation domain one (AF1) and presence of the activation domain 2 (AF2) trigger the ubiquitination of the receptors. Moreover, heterodimerization of RAR and RXR accelerate degradation of the receptors. (This definition may be outdated - see the DesignNote.)" @default.