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- B4a738bf1b3ec29e354dba817f9b91ad7 NCIT_P378 "NCI" @default.
- B4a738bf1b3ec29e354dba817f9b91ad7 type Axiom @default.
- B4a738bf1b3ec29e354dba817f9b91ad7 annotatedProperty IAO_0000115 @default.
- B4a738bf1b3ec29e354dba817f9b91ad7 annotatedSource NCIT_C67504 @default.
- B4a738bf1b3ec29e354dba817f9b91ad7 annotatedTarget "A liposomal formulation containing a fixed combination of the antineoplastic agents cytarabine and daunorubicin in a 5:1 molar ratio. Liposome-encapsulated daunorubicin-cytarabine has been designed to provide optimal delivery of a specific ratio of cytarabine to daunorubicin, one that has been shown to be synergistic in vitro. The antimetabolite cytarabine competes with cytidine for incorporation into DNA, inhibiting DNA synthesis. This agent also inhibits DNA polymerase, resulting in a decrease in DNA replication and repair. Daunorubicin, an intercalator and a topoisomerase II inhibitor, prevents DNA replication and inhibits protein synthesis. This agent also generates oxygen free radicals, resulting in the cytotoxic lipid peroxidation of cell membrane lipids." @default.