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- B4b4342ee15eeeb6b72f1245faae21184 NCIT_P378 "NCI" @default.
- B4b4342ee15eeeb6b72f1245faae21184 type Axiom @default.
- B4b4342ee15eeeb6b72f1245faae21184 annotatedProperty IAO_0000115 @default.
- B4b4342ee15eeeb6b72f1245faae21184 annotatedSource NCIT_C148241 @default.
- B4b4342ee15eeeb6b72f1245faae21184 annotatedTarget "A cancer vaccine consisting of autologous dendritic cells (DCs) transduced with a recombinant replication-defective adenoviral (Ad) vector encoding the full-length wild-type (wt) cancer tumor antigen p53 protein (TP53; p53), with potential immunomodulating activity. Intradermal vaccination with the autologous DCs transduced with wt p53 Ad vaccine may stimulate the host immune system to mount a cytotoxic T-lymphocyte (CTL) response against tumor cells overexpressing wt and mutant forms of p53, resulting in tumor cell lysis. p53, a tumor suppressor gene, is overexpressed and/or mutated in many tumor cells, resulting in the loss of apoptosis regulation and abnormal cell proliferation." @default.