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- B4b653046d3e2728c1de0d95e76c8f148 NCIT_P378 "NCI" @default.
- B4b653046d3e2728c1de0d95e76c8f148 type Axiom @default.
- B4b653046d3e2728c1de0d95e76c8f148 annotatedProperty IAO_0000115 @default.
- B4b653046d3e2728c1de0d95e76c8f148 annotatedSource NCIT_C513 @default.
- B4b653046d3e2728c1de0d95e76c8f148 annotatedTarget "A congener of the antimetabolite fluorouracil with antineoplastic activity. Tegafur is a prodrug that is gradually converted to fluorouracil in the liver by the cytochrome P-450 enzyme. Subsequently, 5-FU is metabolized to two active metabolites, 5-fluoro-2-deoxyuridine monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP) by both tumor cells and normal cells. FdUMP inhibits DNA synthesis and cell division by inhibiting thymidylate synthase and reducing normal thymidine production, while FUTP inhibits RNA and protein synthesis by competing with uridine triphosphate. (NCI04)" @default.