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- B4b809f44487e00558237d46e3b00a4a0 NCIT_P378 "NCI" @default.
- B4b809f44487e00558237d46e3b00a4a0 type Axiom @default.
- B4b809f44487e00558237d46e3b00a4a0 annotatedProperty IAO_0000115 @default.
- B4b809f44487e00558237d46e3b00a4a0 annotatedSource NCIT_C1176 @default.
- B4b809f44487e00558237d46e3b00a4a0 annotatedTarget "A prodrug of mesalamine (5-Aminosalicylic acid; 5-ASA) with anti-inflammatory activity. Unabsorbed olsalazine passes through gastrointestinal tract and is cleaved by azoreductases, produced by microflora in colon, into 2 active molecules of 5-ASA. 5-ASA exerts its anti-inflammatory action locally by inhibiting cyclooxygenase and lipoxygenase activities, thereby reducing the production of prostaglandins and leukotrienes. In addition, mesalamine may act as a scavenger of reactive oxygen free radicals." @default.