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- B4bee706ef2ed6f5a8279f0579d27dd19 NCIT_P378 "NCI" @default.
- B4bee706ef2ed6f5a8279f0579d27dd19 type Axiom @default.
- B4bee706ef2ed6f5a8279f0579d27dd19 annotatedProperty IAO_0000115 @default.
- B4bee706ef2ed6f5a8279f0579d27dd19 annotatedSource NCIT_C47476 @default.
- B4bee706ef2ed6f5a8279f0579d27dd19 annotatedTarget "A synthetic progestogen structurally related to levonorgestrel, with progesterone hormone receptor agonistic activity, used as a contraceptive and hormone replacement agent. Upon administration, desogestrel binds intracellular progesterone receptors in progesterone responsive tissue and the resultant complex interacts with DNA causing either gene transcription or gene repression. This eventually leads to an inhibition of gonadotropin releasing hormone (GnRH) secretion from the hypothalamus and a subsequent inhibition of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) release. This prevents ovulation and alters the cervical mucus." @default.