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- B4c770a267d6f7253fde5cc54c93b19b5 NCIT_P378 "NCI" @default.
- B4c770a267d6f7253fde5cc54c93b19b5 type Axiom @default.
- B4c770a267d6f7253fde5cc54c93b19b5 annotatedProperty IAO_0000115 @default.
- B4c770a267d6f7253fde5cc54c93b19b5 annotatedSource NCIT_C16479 @default.
- B4c770a267d6f7253fde5cc54c93b19b5 annotatedTarget "Most cellular effects of cAMP are mediated through PKA by serine or threonine phosphorylation of target proteins. Human Protein Kinase A (cAMP Ser/Thr Protein Kinase Family) is an inactive tetrameric cytoplasmic holoenzyme composed of homo- or heterodimeric regulatory subunits associated with two catalytic subunits. cAMP causes dissociation of inactive holoenzyme into a cAMP-bound dimer of regulatory subunits and two free monomeric catalytic subunits that phosphorylate many cytoplasmic and nuclear substrates. In human, regulatory PRKAR1A, PRKAR1B, PRKAR2A, and PRKAR2B subunits and catalytic PRKACA, PRKACB, and PRKACG subunits have been identified. (NCI)" @default.