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- B4d1da02d40ede4ca05a0b749a693340a NCIT_P378 "NCI" @default.
- B4d1da02d40ede4ca05a0b749a693340a type Axiom @default.
- B4d1da02d40ede4ca05a0b749a693340a annotatedProperty IAO_0000115 @default.
- B4d1da02d40ede4ca05a0b749a693340a annotatedSource NCIT_C155981 @default.
- B4d1da02d40ede4ca05a0b749a693340a annotatedTarget "A mixture of single-stranded oligodeoxyribonucleotides derived from the intestinal mucosa of pigs, with anti-thrombotic, thrombolytic, and fibrinolytic activities. Upon administration, and although the exact mechanism of action has yet to be fully elucidated, defibrotide induces the release of prostaglandin I2 (PGI2), E2 (PGE2), and prostacyclin and reduces the expression of adhesion molecules on endothelial cells. This relaxes the smooth muscle of blood vessels and prevents platelets from adhering to each other and to the endothelium. This protects the endothelium lining bloods vessels. Defibrotide increases tissue plasminogen activator (t-PA) and decreases plasminogen activator inhibitor-1 activity. This increases the activity of plasmin, prevents blood clot formation and dissolves blood clots." @default.