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- B4d414ec7ce6f87461ad0472347c60c1d NCIT_P378 "NCI" @default.
- B4d414ec7ce6f87461ad0472347c60c1d type Axiom @default.
- B4d414ec7ce6f87461ad0472347c60c1d annotatedProperty IAO_0000115 @default.
- B4d414ec7ce6f87461ad0472347c60c1d annotatedSource NCIT_C132257 @default.
- B4d414ec7ce6f87461ad0472347c60c1d annotatedTarget "A proprietary, suppository-based formulation composed of idronoxil, a synthetic flavonoid derivative, surrounded by a proprietary lipid that protects idronoxil from phase 2 degradation, with potential chemo- and radio-sensitizing activities. Upon administration, idronoxil blocks the activity of ecto-NOX disulfide-thiol exchanger 2 (ENOX2; tNOX), a tumor-specific external NADH oxidase that maintains the transmembrane electron potential across the plasma membrane and is overexpressed in certain cancer cell types while absent in normal, healthy cells. Loss of this potential directly inhibits certain pro-survival signal transduction pathways, such as the PARP1/PI3 kinase/Akt signaling pathway. The inhibition of these pathways prevents resistance to standard chemo- and radio-therapy and makes tumor cells more susceptible to the anti-tumor activity of conventional chemotherapeutic agents and radiotherapy. The formulation prevents detoxification of idronoxil to an inactive form by bypassing phase 2 metabolism; this increases idronoxil's bioavailability as compared to idronoxil alone." @default.