Matches in Ubergraph for { <https://frink.apps.renci.org/.well-known/genid/B4d49b2b49e82e9ec5eac1d0770b81a07> ?p ?o ?g. }
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- B4d49b2b49e82e9ec5eac1d0770b81a07 NCIT_P378 "NCI" @default.
- B4d49b2b49e82e9ec5eac1d0770b81a07 type Axiom @default.
- B4d49b2b49e82e9ec5eac1d0770b81a07 annotatedProperty IAO_0000115 @default.
- B4d49b2b49e82e9ec5eac1d0770b81a07 annotatedSource NCIT_C175560 @default.
- B4d49b2b49e82e9ec5eac1d0770b81a07 annotatedTarget "A fixed combination of praziquantel and pyrantel pamoate, with anthelminthic activity. Upon administration, praziquantel increases the permeability of the tegument of susceptible worms, resulting in an influx and increase in intra-tegumental calcium leading to rapid contractions and paralysis of the worm's musculature. In addition, vacuolization of the tegumental syncytium and blebbing results in tegument disintegration, leads to antigen exposure and elicit host defense responses to the worm. This results in granulomas formation and phagocytosis. Pyrantel pamoate acts as a depolarizing neuromuscular blocking agent resulting in spastic paralysis of the helminths. The parasites are then eliminated through intestinal tract peristalsis of the host." @default.