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- B4da505e8b842f3d048b98c168233379e NCIT_P378 "NCI" @default.
- B4da505e8b842f3d048b98c168233379e type Axiom @default.
- B4da505e8b842f3d048b98c168233379e annotatedProperty IAO_0000115 @default.
- B4da505e8b842f3d048b98c168233379e annotatedSource NCIT_C103277 @default.
- B4da505e8b842f3d048b98c168233379e annotatedTarget "An inhibitor of the beta and delta isoforms of the 110 kDa catalytic subunit of class IA phosphoinositide-3 kinases (PI3K) with potential immunomodulating and antineoplastic activities. Acalisib inhibits the activity of PI3K, thereby preventing the production of the second messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3), which decreases tumor cell proliferation and induces cell death. PI3K-mediated signaling is often dysregulated in cancer cells; the targeted inhibition of PI3K is designed to preserve PI3K signaling in normal, non-neoplastic cells." @default.