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- B4e257664cb6a46c9df9d4b4d8d3c5807 NCIT_P378 "NCI" @default.
- B4e257664cb6a46c9df9d4b4d8d3c5807 type Axiom @default.
- B4e257664cb6a46c9df9d4b4d8d3c5807 annotatedProperty IAO_0000115 @default.
- B4e257664cb6a46c9df9d4b4d8d3c5807 annotatedSource NCIT_C1212 @default.
- B4e257664cb6a46c9df9d4b4d8d3c5807 annotatedTarget "A natural macrocyclic lactone produced by the bacterium Streptomyces hygroscopicus, with immunosuppressant properties. In cells, sirolimus binds to the immunophilin FK Binding Protein-12 (FKBP-12) to generate an immunosuppressive complex that binds to and inhibits the activation of the mammalian Target Of Rapamycin (mTOR), a key regulatory kinase. This results in inhibition of T lymphocyte activation and proliferation that occurs in response to antigenic and cytokine (IL-2, IL-4, and IL-15) stimulation and inhibition of antibody production. (NCI04)" @default.