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- B4e7cc62ef6f4233066defadb2c58be88 NCIT_P378 "NCI" @default.
- B4e7cc62ef6f4233066defadb2c58be88 type Axiom @default.
- B4e7cc62ef6f4233066defadb2c58be88 annotatedProperty IAO_0000115 @default.
- B4e7cc62ef6f4233066defadb2c58be88 annotatedSource NCIT_C71631 @default.
- B4e7cc62ef6f4233066defadb2c58be88 annotatedTarget "A derivative of folic acid with chemoprotectant, antidote and synergistic activity. Leucovorin does not require metabolism by dihydrofolate reductase, the molecular target of folate antagonist-type chemotherapeutic drugs, and is converted to a tetrahydrofolate, which is the necessary folate for purine and pyrimidine synthesis. As this agent allows for some purine/pyrimidine synthesis to occur, the toxic effects of folic acid antagonist-type chemotherapeutic drugs are counteracted while still permitting the antitumor activity of the folic acid antagonist through dihydrofolate reductase inhibition. This agent also potentiates the effects of 5-fluorouracil and its derivatives by stabilizing the binding of 5-fluorouracil's converted form fluorodeoxyuridylic acid to its target enzyme thymidylate synthase, thus prolonging drug activity." @default.