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- B4ed311116c143826f8212caac659de1c NCIT_P378 "NCI" @default.
- B4ed311116c143826f8212caac659de1c type Axiom @default.
- B4ed311116c143826f8212caac659de1c annotatedProperty IAO_0000115 @default.
- B4ed311116c143826f8212caac659de1c annotatedSource NCIT_C105401 @default.
- B4ed311116c143826f8212caac659de1c annotatedTarget "An orally bioavailable, synthetic analog of the fatty acid oleic acid, with potential antitumor activity. Upon administration,idroxioleic acid activates sphingomyelin synthase (SMS), thereby increasing the concentration of sphingomyelin (SM) and diacylglycerol (DAG) in the tumor cell membrane and decreasing membrane levels of phosphatidylethanolamine (PE) and phosphatidylcholine (PC). This restores the normal, healthy levels and ratios of membrane lipids. By restoring normal membrane lipid structure and composition, this agent inhibits membrane-protein associated signaling and the aberrant activity of signaling pathways in certain tumor cells, including the Ras/MAPK and PI3K/AKt pathways. This inhibits tumor cell proliferation, induces tumor cell differentiation, and eventually can cause cell death." @default.