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- B4ed427537843d39433099b17ec7350dc NCIT_P378 "NCI" @default.
- B4ed427537843d39433099b17ec7350dc type Axiom @default.
- B4ed427537843d39433099b17ec7350dc annotatedProperty IAO_0000115 @default.
- B4ed427537843d39433099b17ec7350dc annotatedSource NCIT_C29366 @default.
- B4ed427537843d39433099b17ec7350dc annotatedTarget "The hydrochloride salt form of pimonidazole, a hypoxia-selective 2-nitroimidazole with potential radiosensitizing activity. Pimonidazole is reduced in hypoxic environments such as those found in tumors. In hypoxic cells and tumors, reduced pimonidazole binds to thiol-containing proteins and glutathione. The resulting complexes accumulate in hypoxic tumors, deplete radioprotective thiol compounds, and cause the tumor to be more susceptible to radiation treatment." @default.