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- B4f55bd6fe8aabb623f85817d50e36616 NCIT_P378 "NCI" @default.
- B4f55bd6fe8aabb623f85817d50e36616 type Axiom @default.
- B4f55bd6fe8aabb623f85817d50e36616 annotatedProperty IAO_0000115 @default.
- B4f55bd6fe8aabb623f85817d50e36616 annotatedSource NCIT_C62044 @default.
- B4f55bd6fe8aabb623f85817d50e36616 annotatedTarget "A synthetic opioid with analgesic activity. Methadone mimics the actions of endogenous peptides at CNS opioid receptors, primarily on the mu-receptor and has actions similar to those of morphine and morphine-like agents. The characteristic morphine-like effects include analgesia, euphoria, sedation, respiratory depression, miosis, bradycardia and physical dependence. However, the detoxification symptoms between morphine-like agents and methadone differ in that the onset of methadone's withdrawal symptoms is slower, the course is more prolonged and the symptoms are less severe." @default.