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- B50179fd73d23440c0c81c58f30758722 NCIT_P378 "NCI" @default.
- B50179fd73d23440c0c81c58f30758722 type Axiom @default.
- B50179fd73d23440c0c81c58f30758722 annotatedProperty IAO_0000115 @default.
- B50179fd73d23440c0c81c58f30758722 annotatedSource NCIT_C872 @default.
- B50179fd73d23440c0c81c58f30758722 annotatedTarget "A natural alkaloid derivative of xanthine isolated from the plants Camellia sinensis and Coffea arabica. Theophylline appears to inhibit phosphodiesterase and prostaglandin production, regulate calcium flux and intracellular calcium distribution, and antagonize adenosine. Physiologically, this agent relaxes bronchial smooth muscle, produces vasodilation (except in cerebral vessels), stimulates the CNS, stimulates cardiac muscle, induces diuresis, and increases gastric acid secretion; it may also suppress inflammation and improve contractility of the diaphragm. (NCI04)" @default.