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- B501cec93612c6448251f7a4cd36f1736 NCIT_P378 "NCI" @default.
- B501cec93612c6448251f7a4cd36f1736 type Axiom @default.
- B501cec93612c6448251f7a4cd36f1736 annotatedProperty IAO_0000115 @default.
- B501cec93612c6448251f7a4cd36f1736 annotatedSource NCIT_C61893 @default.
- B501cec93612c6448251f7a4cd36f1736 annotatedTarget "A short-acting, beta-adrenergic receptor agonist with bronchodilator activity. Pirbuterol selectively binds to beta-2 adrenergic receptors in bronchial smooth muscle, thereby activating intracellular adenyl cyclase, an enzyme that catalyzes the conversion of adenosine triphosphate (ATP) to cyclic-3',5'-adenosine monophosphate (cAMP). Increased cAMP levels cause relaxation of bronchial smooth muscle, relieve bronchospasms, improve mucociliary clearance and inhibit the release of mediators of immediate hypersensitivity from cells, especially from mast cells." @default.