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- B50592271787b5135a740e5f6489c8c8d NCIT_P378 "NCI" @default.
- B50592271787b5135a740e5f6489c8c8d type Axiom @default.
- B50592271787b5135a740e5f6489c8c8d annotatedProperty IAO_0000115 @default.
- B50592271787b5135a740e5f6489c8c8d annotatedSource NCIT_C1003 @default.
- B50592271787b5135a740e5f6489c8c8d annotatedTarget "An antineoplastic antibiotic of macrocyclic benzoquinone isolated from the bacterial genus Streptomyces. Ansamycin antibiotics bind to and inhibit the cytosolic chaperone functions of heat shock protein 90 (HSP90). HSP90 maintains the stability and functional shape of many oncogenic signaling proteins and the inhibition of HSP90 promotes the proteasomal degradation of oncogenic signaling proteins that may be over-expressed or overactive in tumor cells." @default.