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- B50b2f919845d3dd6d3c47eb83dfd7333 NCIT_P378 "KEGG" @default.
- B50b2f919845d3dd6d3c47eb83dfd7333 type Axiom @default.
- B50b2f919845d3dd6d3c47eb83dfd7333 annotatedProperty NCIT_P325 @default.
- B50b2f919845d3dd6d3c47eb83dfd7333 annotatedSource NCIT_C91457 @default.
- B50b2f919845d3dd6d3c47eb83dfd7333 annotatedTarget "Base excision repair (BER) is the predominant DNA damage repair pathway for the processing of small base lesions, derived from oxidation and alkylation damages. BER is normally defined as DNA repair initiated by lesion-specific DNA glycosylases and completed by either of the two sub-pathways: short-patch BER where only one nucleotide is replaced and long-patch BER where 2-13 nucleotides are replaced. Each sub-pathway of BER relies on the formation of protein complexes that assemble at the site of the DNA lesion and facilitate repair in a coordinated fashion. This process of complex formation appears to provide an increase in specificity and efficiency to the BER pathway, thereby facilitating the maintenance of genome integrity by preventing the accumulation of highly toxic repair intermediates." @default.