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- B510d7f51071640e2e9cc0795958b6c1a NCIT_P378 "NCI" @default.
- B510d7f51071640e2e9cc0795958b6c1a type Axiom @default.
- B510d7f51071640e2e9cc0795958b6c1a annotatedProperty IAO_0000115 @default.
- B510d7f51071640e2e9cc0795958b6c1a annotatedSource NCIT_C131874 @default.
- B510d7f51071640e2e9cc0795958b6c1a annotatedTarget "An orally bioavailable androgen receptor (AR) antagonist, with potential antineoplastic activity. Upon oral administration, AR antagonist TRC253 specifically binds to both wild-type and certain mutant forms of AR, thereby preventing androgen-induced receptor activation and facilitating the formation of inactive complexes that cannot translocate to the nucleus. This prevents binding to and transcription of AR-responsive genes, inhibits the expression of genes that regulate prostate cancer cell proliferation, and may lead to an inhibition of growth of tumor cells in which AR is overexpressed and/or mutated. AR is often overexpressed and/or mutated in prostate cancers and plays a key role in proliferation, survival and chemoresistance of tumor cells." @default.