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- B5140870527618b65a291ffcd4f45fe06 NCIT_P378 "NCI" @default.
- B5140870527618b65a291ffcd4f45fe06 type Axiom @default.
- B5140870527618b65a291ffcd4f45fe06 annotatedProperty IAO_0000115 @default.
- B5140870527618b65a291ffcd4f45fe06 annotatedSource NCIT_C290 @default.
- B5140870527618b65a291ffcd4f45fe06 annotatedTarget "A purine analogue with cytotoxic and immunosuppressive activity. Azathioprine is a prodrug that is converted by hepatic xanthine oxidase to its active metabolite 6-mercaptopurine (6-MP). 6-MP is further metabolized by hypoxanthine-guanine phosphoribosyltransferase (HGPRT) into 6-thioguanosine-5'-phosphate (6-thio-GMP) and 6-thioinosine monophosphate (6-thio-IMP), both inhibit nucleotide conversions and de novo purine synthesis. This leads to inhibition of DNA, RNA, and protein synthesis. As a result, cell proliferation may be inhibited, particularly in lymphocytes and leukocytes." @default.