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- B51477afb44e7891762354ccd45d6f228 NCIT_P378 "NCI" @default.
- B51477afb44e7891762354ccd45d6f228 type Axiom @default.
- B51477afb44e7891762354ccd45d6f228 annotatedProperty IAO_0000115 @default.
- B51477afb44e7891762354ccd45d6f228 annotatedSource NCIT_C62201 @default.
- B51477afb44e7891762354ccd45d6f228 annotatedTarget "The deoxycholate salt of amphotericin B, a polyene antifungal antibiotic produced by Streptomyces nodosus, with antifungal activity. Amphotericin B binds to ergosterol, an essential component of the fungal cell membrane. This results in depolarization of the cell membrane, alterations in cell membrane permeability, leakage of important intracellular components, and cell rupture. This agent may also induce oxidative damage in fungal cells and has been reported to stimulate host immune cells." @default.