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- B515cec268ac5b510ac48c98c27e7bb05 NCIT_P378 "NCI" @default.
- B515cec268ac5b510ac48c98c27e7bb05 type Axiom @default.
- B515cec268ac5b510ac48c98c27e7bb05 annotatedProperty IAO_0000115 @default.
- B515cec268ac5b510ac48c98c27e7bb05 annotatedSource NCIT_C200344 @default.
- B515cec268ac5b510ac48c98c27e7bb05 annotatedTarget "A preparation of umbilical cord blood (CB)-derived natural killer cells (NKs) that have been engineered to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) trophoblast cell surface protein 2 (trophoblast antigen 2; tumor-associated calcium signal transducer 2; TROP2; TROP-2; TACSTD2; GA733-1; M1S1) and interleukin-15 (IL-15), with potential immunostimulating and antineoplastic activities. Upon administration, anti-TROP2-CAR-IL-15-transduced CB-derived NK cells target, bind to and induce selective cytotoxicity in TROP2-expressing tumor cells. IL-15 is a pro-survival cytokine that promotes persistence of multiple lymphocyte lineages and potentiates the immune response against tumor cells. TROP2 is a transmembrane protein overexpressed in various tumors. Its expression is associated with enhanced tumor aggressiveness, metastasis, drug resistance and increased tumor cell survival." @default.