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- B519a4f1f55f2fa0ac12d392f46197216 NCIT_P378 "NCI" @default.
- B519a4f1f55f2fa0ac12d392f46197216 type Axiom @default.
- B519a4f1f55f2fa0ac12d392f46197216 annotatedProperty IAO_0000115 @default.
- B519a4f1f55f2fa0ac12d392f46197216 annotatedSource NCIT_C62483 @default.
- B519a4f1f55f2fa0ac12d392f46197216 annotatedTarget "A chimeric IgG1 monoclonal antibody against human mesothelin with potential anti-tumor activity. Amatuximab specifically targets mesothelin, a cell surface glycoprotein involved in cell adhesion and overexpressed on many epithelial-derived cancer cells. Upon binding to the mesothelin antigen, amatuximab triggers an antibody dependent cellular cytotoxicity (ADCC)-mediated host immune response against mesothelin-expressing cells, resulting in cell lysis." @default.