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- B51fc217c9292d60ca8bb06c609734d9c NCIT_P378 "BIOCARTA" @default.
- B51fc217c9292d60ca8bb06c609734d9c type Axiom @default.
- B51fc217c9292d60ca8bb06c609734d9c annotatedProperty NCIT_P325 @default.
- B51fc217c9292d60ca8bb06c609734d9c annotatedSource NCIT_C39260 @default.
- B51fc217c9292d60ca8bb06c609734d9c annotatedTarget "As tissues grow they require angiogenesis to occur if they are to be supplied with blood vessels and survive. Factors that inhibit angiogenesis might act as cancer therapeutics by blocking vessel formation in tumors and starving cancer cells. Thrombospondin-1 (TSP-1) is a protein that inhibits angiogenesis and slows tumor growth, apparently by inducing apoptosis of microvascular endothelial cells that line blood vessels. TSP-1 appears to produce this response by activating a signaling pathway that begins with its receptor, CD36, at the cell surface of the microvascular endothelial cell. The non-receptor tyrosine kinase fyn is activated by TSP-1 through CD36, activating the apoptosis inducing proteases such as caspase-3 and p38 protein kinases. p38 is a mitogen-activated kinase that also induces apoptosis in some conditions, perhaps through AP-1 activation and the activation of genes that lead to apoptosis. (This definition may be outdated - see the DesignNote.)" @default.