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- B52d05bc2247d5e898895451c4015b294 NCIT_P378 "BIOCARTA" @default.
- B52d05bc2247d5e898895451c4015b294 type Axiom @default.
- B52d05bc2247d5e898895451c4015b294 annotatedProperty NCIT_P325 @default.
- B52d05bc2247d5e898895451c4015b294 annotatedSource NCIT_C39096 @default.
- B52d05bc2247d5e898895451c4015b294 annotatedTarget "G-aS-coupled receptors stimulate adenylyl cyclase (AC), which synthesizes cAMP from ATP. In contrast Gai-coupled receptors inhibit AC and so reduce cAMP formation. The bg subunits from Gai and other G proteins are able to activate the MAP kinase pathways and PLCb. GPCRs coupled to the Gaq family of G proteins stimulate PLCb, which cleaves membrane phospholipids to produce IP3, which mobilizes intracellular calcium, and DAG, which activates PKC. Second messenger pathways then activate a range of effector systems to change cell behavior; in many cases this includes the regulation of gene transcription. (This definition may be outdated - see the DesignNote.)" @default.