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- B539e7040b94e9e86298fa4138c62beb2 NCIT_P378 "NCI" @default.
- B539e7040b94e9e86298fa4138c62beb2 type Axiom @default.
- B539e7040b94e9e86298fa4138c62beb2 annotatedProperty IAO_0000115 @default.
- B539e7040b94e9e86298fa4138c62beb2 annotatedSource NCIT_C97660 @default.
- B539e7040b94e9e86298fa4138c62beb2 annotatedTarget "An orally available cyclin-dependent kinase (CDK) inhibitor that targets the CDK4 (cyclin D1) and CDK6 (cyclin D3) cell cycle pathway, with potential antineoplastic activity. Abemaciclib specifically inhibits CDK4 and 6, thereby inhibiting retinoblastoma (Rb) protein phosphorylation in early G1. Inhibition of Rb phosphorylation prevents CDK-mediated G1-S phase transition, thereby arresting the cell cycle in the G1 phase, suppressing DNA synthesis and inhibiting cancer cell growth. Overexpression of the serine/threonine kinases CDK4/6, as seen in certain types of cancer, causes cell cycle deregulation." @default.