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- B546557a5ab1a7dc72bf8a45630e49bdf NCIT_P378 "NCI" @default.
- B546557a5ab1a7dc72bf8a45630e49bdf type Axiom @default.
- B546557a5ab1a7dc72bf8a45630e49bdf annotatedProperty IAO_0000115 @default.
- B546557a5ab1a7dc72bf8a45630e49bdf annotatedSource NCIT_C679 @default.
- B546557a5ab1a7dc72bf8a45630e49bdf annotatedTarget "The hydrochloride salt of naltrexone, a noroxymorphone derivative with competitive opioid antagonistic activity. Naltrexone and its metabolite 6-beta-naltrexol reverse the effects of opioids by binding to various opioid receptors in the central nervous system CNS), including the mu-, kappa- and gamma-opioid receptors; opioid effects of analgesia, euphoria, sedation, respiratory depression, miosis, bradycardia, and physical dependence are inhibited. Naltrexone is longer-acting and more potent compared to naloxone." @default.