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- B55224563a1fc77e136e977a685d21ce8 NCIT_P378 "NCI" @default.
- B55224563a1fc77e136e977a685d21ce8 type Axiom @default.
- B55224563a1fc77e136e977a685d21ce8 annotatedProperty IAO_0000115 @default.
- B55224563a1fc77e136e977a685d21ce8 annotatedSource NCIT_C120302 @default.
- B55224563a1fc77e136e977a685d21ce8 annotatedTarget "An orally available human C-C chemokine receptor type 2 (CCR2) antagonist, with potential immunomodulating and antineoplastic activities. Upon oral administration, CCR2 antagonist CCX872-B specifically binds to CCR2 and prevents the binding its cognate endothelium-derived chemokine ligand CCL2 (monocyte chemoattractant protein-1 or MCP1). This may result in the inhibition of both CCR2 activation and CCR2-mediated signal transduction, which may inhibit inflammatory processes, angiogenesis, tumor cell migration, and tumor cell proliferation. The G-protein coupled receptor CCR2 is expressed on the surface of monocytes and macrophages, and stimulates their migration and infiltration; it plays a key role in inflammation. CCR2 is overexpressed in certain cancer cell types, where it is involved in angiogenesis, tumor cell migration and proliferation." @default.