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- B553512ccbb151e5929136d90ca8e71a9 NCIT_P378 "NCI" @default.
- B553512ccbb151e5929136d90ca8e71a9 type Axiom @default.
- B553512ccbb151e5929136d90ca8e71a9 annotatedProperty IAO_0000115 @default.
- B553512ccbb151e5929136d90ca8e71a9 annotatedSource NCIT_C165747 @default.
- B553512ccbb151e5929136d90ca8e71a9 annotatedTarget "An orally bioavailable inhibitor of cyclin-dependent kinases 8 and 19 (CDK8/19), with potential antineoplastic and chemoprotective activities. Upon oral administration, CDK8/19 inhibitor SEL 120 targets, binds to and inhibits the activity of CDK8/19, which prevents activation of CDK8/19-mediated oncogenic signaling pathways, blocks selective transcription of various tumor-promoting genes, and inhibits proliferation of CDK8/19-overexpressing tumor cells. CDK8/19, serine/threonine kinases involved in the regulation of the cell cycle, are overexpressed in certain cancer cell types and play key roles in tumor cell proliferation." @default.