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- B553b53171b01d90507e41c1e18c545d3 NCIT_P378 "NCI" @default.
- B553b53171b01d90507e41c1e18c545d3 type Axiom @default.
- B553b53171b01d90507e41c1e18c545d3 annotatedProperty IAO_0000115 @default.
- B553b53171b01d90507e41c1e18c545d3 annotatedSource NCIT_C61753 @default.
- B553b53171b01d90507e41c1e18c545d3 annotatedTarget "The sodium salt of ertapenem, a 1-beta-methyl carbapenem and a broad-spectrum beta-lactam antibiotic with bactericidal activity. Ertapenem binds to penicillin binding proteins (PBPs) located on the bacterial cell wall, in particular PBPs 2 and 3, thereby inhibiting the final transpeptidation step in the synthesis of peptidoglycan, an essential component of the bacterial cell wall. Inhibition of peptidoglycan synthesis results in weakening and lysis of the cell wall and cell death. In vitro, this agent has shown activity against Gram-positive and Gram-negative aerobic and anaerobic bacteria. Erapenem is resistant to hydrolysis by a variety of beta-lactamases, including penicillinases, cephalosporinases and extended-spectrum beta-lactamases." @default.