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- B553e782bc121c878df357336aeeec570 NCIT_P378 "NCI" @default.
- B553e782bc121c878df357336aeeec570 type Axiom @default.
- B553e782bc121c878df357336aeeec570 annotatedProperty IAO_0000115 @default.
- B553e782bc121c878df357336aeeec570 annotatedSource NCIT_C104744 @default.
- B553e782bc121c878df357336aeeec570 annotatedTarget "An orally available inhibitor of extracellular signal-regulated kinase (ERK) 1 and 2, with potential antineoplastic activity. Upon oral administration, ulixertinib inhibits both ERK 1 and 2, thereby preventing the activation of ERK-mediated signal transduction pathways. This results in the inhibition of ERK-dependent tumor cell proliferation and survival. The mitogen-activated protein kinase (MAPK)/ERK pathway is often upregulated in a variety of tumor cell types and plays a key role in tumor cell proliferation, differentiation and survival." @default.