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- B561bb54e40e00e988f6dbb048a226de0 hasDbXref "FBC:GM" @default.
- B561bb54e40e00e988f6dbb048a226de0 type Axiom @default.
- B561bb54e40e00e988f6dbb048a226de0 annotatedProperty IAO_0000115 @default.
- B561bb54e40e00e988f6dbb048a226de0 annotatedSource FBcv_0005067 @default.
- B561bb54e40e00e988f6dbb048a226de0 annotatedTarget "Repressor that can be used to regulate expression in a binary expression system and whose activity is regulated by temperature. A binary expression system requires a transactivator ('driver') that binds to a specific DNA sequence ('regulatory region' or 'effector'). A driver encoded by one transgenic locus or modified endogenous locus is used to drive expression of a downstream 'responder' or 'reporter' encoded by another transgenic locus or modified endogenous locus, by fusing the regulatory region sequence to which the driver binds upstream of the responder sequence. The temporal and spatial expression pattern of the responder thus depends on the regulatory elements used to drive expression of the driver. In addition, a specific repressor protein may be available which prevents the transactivator from driving expression, allowing further refinement of the expression pattern of the responder. Use of a temperature conditional repressor permits further refinement of this expression pattern." @default.