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- B56a6fa4534f9615ed801faa1ac3b0951 NCIT_P378 "NCI" @default.
- B56a6fa4534f9615ed801faa1ac3b0951 type Axiom @default.
- B56a6fa4534f9615ed801faa1ac3b0951 annotatedProperty IAO_0000115 @default.
- B56a6fa4534f9615ed801faa1ac3b0951 annotatedSource NCIT_C29047 @default.
- B56a6fa4534f9615ed801faa1ac3b0951 annotatedTarget "A synthetic phenoxy-isobutyric acid derivate and prodrug with antihyperlipidemic activity. Fenofibrate is hydrolyzed in vivo to its active metabolite fenofibric acid that binds to and activates peroxisome proliferator activated receptor alpha (PPARalpha), resulting in the activation of lipoprotein lipase and reduction of the production of apoprotein C-III, an inhibitor of lipoprotein lipase activity. Increased lipolysis and a fall in plasma triglycerides, in turn, leads to the modification of the small, dense low density lipoporotein (LDL) particles into larger particles that are catabolized more rapidly due to a greater affinity for cholesterol receptors. In addition, activation of PPARalpha also increases the synthesis of apoproteins A-I, A-II, and high density lipoprotein (HDL)-cholesterol. Overall, fenofibrate reduces total cholesterol, LDL cholesterol, apolipoprotein B, total triglycerides and triglyceride rich lipoprotein (VLDL) while increasing HDL cholesterol." @default.