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- B56b8da10bf53fef0b25c4cfcf5ba892d NCIT_P378 "NCI" @default.
- B56b8da10bf53fef0b25c4cfcf5ba892d type Axiom @default.
- B56b8da10bf53fef0b25c4cfcf5ba892d annotatedProperty IAO_0000115 @default.
- B56b8da10bf53fef0b25c4cfcf5ba892d annotatedSource NCIT_C321 @default.
- B56b8da10bf53fef0b25c4cfcf5ba892d annotatedTarget "A synthetic derivative of dimethane-sulfonate with antineoplastic and cytotoxic properties. Although its mechanism of action is not fully understood, busulfan appears to act through the alkylation of DNA. Following systemic absorption of busulfan, carbonium ions are formed, resulting in DNA alkylation and DNA breaks and inhibition of DNA replication and RNA transcription. (NCI04)" @default.