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- B56b9a66a990ef8118d94221008b42ab7 NCIT_P378 "NCI" @default.
- B56b9a66a990ef8118d94221008b42ab7 type Axiom @default.
- B56b9a66a990ef8118d94221008b42ab7 annotatedProperty IAO_0000115 @default.
- B56b9a66a990ef8118d94221008b42ab7 annotatedSource NCIT_C61564 @default.
- B56b9a66a990ef8118d94221008b42ab7 annotatedTarget "A bi-fluorinated derivative of the semi-synthetic vinca alkaloid vinorelbine with antitubulin, antineoplastic, and antiangiogenic activities. Vinflunine inhibits tubulin assembly without any stablization of assembled microtubules at concentrations comparable to those of other vinca alkaloids such as vincristine, vinblastine and vinorelbine; this effect on microtubule dynamics results in cell cycle arrest in mitosis and apoptosis. Compared to other vinca alkaloids, this agent binds weakly to the vinca-binding site, indicating that vinflunine may exhibit reduced neurotoxicity." @default.