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- B57b67adfa41fa93c94d73e65eba9a902 NCIT_P378 "NCI" @default.
- B57b67adfa41fa93c94d73e65eba9a902 type Axiom @default.
- B57b67adfa41fa93c94d73e65eba9a902 annotatedProperty IAO_0000115 @default.
- B57b67adfa41fa93c94d73e65eba9a902 annotatedSource NCIT_C47706 @default.
- B57b67adfa41fa93c94d73e65eba9a902 annotatedTarget "The hydrochloride salt form of ritodrine, a phenethylamine derivative with tocolytic activity. Ritodrine hydrochloride binds to and activates beta-2 adrenergic receptors of myocytes in the uterine myometrium, which results in decreased intensity and frequency of uterine contraction. Specifically, ritodrine hydrochloride probably activates adenyl cyclase, thereby increasing production of cyclic adenosine monophosphate (cAMP), which in turn enhancing the efflux of calcium from vascular smooth muscle cells. A lack of intracellular calcium prevents uterine myometrial contraction. In addition, this agent may directly inactivate myosin light chain kinase, a critical enzyme necessary for the initiation of muscle contractions." @default.