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- B57c96bd639a5e4ef68bc12bf81b26cfe NCIT_P378 "NCI" @default.
- B57c96bd639a5e4ef68bc12bf81b26cfe type Axiom @default.
- B57c96bd639a5e4ef68bc12bf81b26cfe annotatedProperty IAO_0000115 @default.
- B57c96bd639a5e4ef68bc12bf81b26cfe annotatedSource NCIT_C62049 @default.
- B57c96bd639a5e4ef68bc12bf81b26cfe annotatedTarget "A short-acting benzodiazepine derivative with an imidazole structure and with anxiolytic, amnestic, hypnotic, anticonvulsant and sedative properties. Midazolam exerts its effect by binding to the benzodiazepine receptor at the gamma-aminobutyric acid (GABA) receptor-chloride ionophore complex in the central nervous system (CNS). This leads to an increase in the opening of chloride channels, membrane hyperpolarization and increases the inhibitory effect of GABA in the CNS. Midazolam may also interfere with the reuptake of GABA, thereby causing accumulation of GABA in the synaptic cleft." @default.