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- B57e81f7e8af81f1343c63492bbfb594b NCIT_P378 "NCI" @default.
- B57e81f7e8af81f1343c63492bbfb594b type Axiom @default.
- B57e81f7e8af81f1343c63492bbfb594b annotatedProperty IAO_0000115 @default.
- B57e81f7e8af81f1343c63492bbfb594b annotatedSource NCIT_C817 @default.
- B57e81f7e8af81f1343c63492bbfb594b annotatedTarget "The sodium salt form of ceftriaxone, a beta-lactam, third-generation cephalosporin antibiotic with bactericidal activity. Ceftriaxone binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. PBPs participate in the terminal stages of assembling the bacterial cell wall, and in reshaping the cell wall during cell division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis. Compared to the second and first generation cephalosporins, ceftriaxone is more active against gram-negative bacteria and less active against gram-positive bacteria. Ceftriaxone also crosses the blood-brain barrier and reaches therapeutic concentrations in the central nervous system (CNS)." @default.