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- B5803271d242773465ef0c0ef14f1a085 NCIT_P378 "NCI" @default.
- B5803271d242773465ef0c0ef14f1a085 type Axiom @default.
- B5803271d242773465ef0c0ef14f1a085 annotatedProperty IAO_0000115 @default.
- B5803271d242773465ef0c0ef14f1a085 annotatedSource NCIT_C930 @default.
- B5803271d242773465ef0c0ef14f1a085 annotatedTarget "A natural alkaloid isolated from the plant Vinca rosea Linn. Vinblastine binds to tubulin and inhibits microtubule formation, resulting in disruption of mitotic spindle assembly and arrest of tumor cells in the M phase of the cell cycle. This agent may also interfere with amino acid, cyclic AMP, and glutathione metabolism; calmodulin-dependent Ca++ -transport ATPase activity; cellular respiration; and nucleic acid and lipid biosynthesis. (NCI04)" @default.