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- B593f64352df6a32a52df20609abf8bb6 NCIT_P378 "NCI" @default.
- B593f64352df6a32a52df20609abf8bb6 type Axiom @default.
- B593f64352df6a32a52df20609abf8bb6 annotatedProperty IAO_0000115 @default.
- B593f64352df6a32a52df20609abf8bb6 annotatedSource NCIT_C29501 @default.
- B593f64352df6a32a52df20609abf8bb6 annotatedTarget "The maleate salt form of timolol, a propanolamine derivative and a non-selective beta-adrenergic antagonist with antihypertensive property. Timolol competitively binds to beta-1-adrenergic receptors in the heart and vascular smooth muscle and beta-2-receptors in the bronchial and vascular smooth muscle, resulting in a decrease in beta-adrenergic stimulation. Beta-1-receptor blockade results in a decrease in resting and exercise heart rate and cardiac output, a decrease in both systolic and diastolic blood pressure, and, possibly, a reduction in reflex orthostatic hypotension. Beta-2-blockade results in an increase in peripheral vascular resistance. The ultimate results include vasodilation, and negative chronotropic and inotropic effects. In addition, timolol reduces intra-ocular pressure possibly by decreasing aqueous humor production by reduction of blood flow to the ciliary processes and cAMP synthesis." @default.