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- B59a799825443b50cdd61c0727ecc7194 NCIT_P378 "NCI" @default.
- B59a799825443b50cdd61c0727ecc7194 type Axiom @default.
- B59a799825443b50cdd61c0727ecc7194 annotatedProperty IAO_0000115 @default.
- B59a799825443b50cdd61c0727ecc7194 annotatedSource NCIT_C29375 @default.
- B59a799825443b50cdd61c0727ecc7194 annotatedTarget "The sodium salt of pravastatin with cholesterol-lowering and potential antineoplastic activities. Pravastatin competitively inhibits hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate, a key step in cholesterol synthesis. This agent lowers plasma cholesterol and lipoprotein levels, and modulates immune responses by suppressing MHC II (major histocompatibility complex II) on interferon gamma-stimulated, antigen-presenting cells such as human vascular endothelial cells. In addition, pravastatin, like other statins, exhibits pro-apoptotic, growth inhibitory, and pro-differentiation activities in a variety of tumor cells; these antineoplastic activities may be due, in part, to inhibition of the isoprenylation of Ras and Rho GTPases and related signaling cascades." @default.