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- B59ca02f3a8995af15e835dd34fffddba NCIT_P378 "NCI" @default.
- B59ca02f3a8995af15e835dd34fffddba type Axiom @default.
- B59ca02f3a8995af15e835dd34fffddba annotatedProperty IAO_0000115 @default.
- B59ca02f3a8995af15e835dd34fffddba annotatedSource NCIT_C129710 @default.
- B59ca02f3a8995af15e835dd34fffddba annotatedTarget "An orally bioavailable, selective inhibitor of Bruton's tyrosine kinase (BTK), with potential antineoplastic activity. Upon administration, M7583 targets and covalently binds to BTK, thereby preventing its activity. This leads to an inhibition of B cell receptor (BCR) signaling and inhibits cell proliferation of B-cell malignancies. BTK, a cytoplasmic tyrosine kinase and member of the Tec family of kinases, plays an important role in B lymphocyte development, activation, signaling, proliferation and survival." @default.