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- B59f990fe44c595fde83c19faccc97e6c NCIT_P378 "NCI" @default.
- B59f990fe44c595fde83c19faccc97e6c type Axiom @default.
- B59f990fe44c595fde83c19faccc97e6c annotatedProperty IAO_0000115 @default.
- B59f990fe44c595fde83c19faccc97e6c annotatedSource NCIT_C102852 @default.
- B59f990fe44c595fde83c19faccc97e6c annotatedTarget "An orally available, small molecule inhibitor of vascular endothelial growth factor receptors (VEGFRs), with potential anti-angiogenic and antineoplastic activities. Upon oral administration, fruquintinib inhibits VEGF-induced phosphorylation of VEGFRs 1, 2, and 3 which may result in the inhibition of migration, proliferation and survival of endothelial cells, microvessel formation, the inhibition of tumor cell proliferation, and tumor cell death. Expression of VEGFRs may be upregulated in a variety of tumor cell types." @default.