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- B5a3363a5429b902c369d94fc54e96674 NCIT_P378 "NCI" @default.
- B5a3363a5429b902c369d94fc54e96674 type Axiom @default.
- B5a3363a5429b902c369d94fc54e96674 annotatedProperty IAO_0000115 @default.
- B5a3363a5429b902c369d94fc54e96674 annotatedSource NCIT_C1539 @default.
- B5a3363a5429b902c369d94fc54e96674 annotatedTarget "A synthetic pyrimidine nucleoside analogue with potential antineoplastic activity. Phosphorylated by cellular kinases, tezacitabine is converted into its active diphosphate and triphosphate metabolites. Tezacitabine diphosphate binds to and irreversibly inhibits the activity of the enzyme ribonucleotide reductase (RNR), which may result in the inhibition of DNA synthesis in tumor cells and tumor cell apoptosis. Tezacitabine triphosphate acts as a substrate for DNA polymerase, further compromising DNA replication. This agent is relatively resistant to metabolic deactivation by cytidine deaminase. RNR catalyzes the conversion of ribonucleoside 5'-diphosphates to deoxyribonucleoside 5'-diphosphates necessary for DNA synthesis and is overexpressed in many tumor types." @default.